Our data overall suggest that diet during the complementary feeding period has a profound impact on the serum metabolome. Long-term impacts remain to be assessed.
The Nordic diet has been shown to reduce adult weight, blood triglyceride levels, and blood pressure, as well as improve blood HDL in randomized control trials. High protein intake during the complementary feeding period in children has been associated with higher weight gain and later onset of obesity. In this study, we compared the effect of feeding a protein-reduced complementary Nordic diet vs a non-Nordic complementary (control) diet on infant plasma metabolomes.
In this randomized controlled trial, infants were randomly assigned to a reduced protein Nordic diet or a regular diet at 4- to 5-months of age (n=125 per group). Infant plasma at 12 and 18 months were sampled and subjected to NMR-based metabolomics analysis.
There were significant differences when comparing the plasma metabolomes of infants in the Nordic diet group compared to the control diet group at both 12 and 18 months. Some of the differences included essential and non-essential amino acid concentrations, urea, and energy metabolite concentrations.
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